The newest endpoints Operating https://worldbrides.org/sv/asiatisk/ system, AFS, and you will freedom off amputation was analysed playing with multivariable day-built Cox regression models within the a full design (most of the people) with sex-communications terminology for every single exposure grounds. This new patterns getting independence off amputation sensed dying because the a contending risk in contrast to the newest AFS models, including dying on the endpoint. For this reason, i put Good and Gray’s approach to estimate sandwich-distributional possibility rates (HRs) about AFS design.

The models included risk profiles of patients at baseline and additionally time-dependent occurrence of comorbidities or procedures in the follow-up period. Thus, we evaluated the interaction of sex with all variables in the Cox regression models. Two-sided P-values for the test of interaction of the two models were jointly adjusted using the Benjamini–Hochberg procedure 34 to control the false discovery rate (FDR) with respect to the multiple testing problem. (más…)